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Casarett & Doull's Toxicology: The Basic Science of Poisons
CONTENTS
UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1
1 history and scope of toxicology 3
Michael A. Gallo
2 principles of toxicology 13
David L. Eaton and Steven G. Gilbert
3 mechanisms of toxicity 49
Zoltan Gregus
4 risk assessment 123
Elaine M. Faustman and Gilbert S. Omenn
UNIT II DISPOSITION OF TOXICANTS 151
5 absorption, distribution, and excretion of toxicants 153
LOis D. Lehman-McKeeman
6 biotransformation of xenobiotics 185
Andrew Parkinson, Brian W. Ogilvie, David B. Buckley, Faraz Kazmi, Maciej Czerwinski, and Oliver Parkinson
UNIT III NON-ORGAN DIRECTED TOXICITY 391
8 chemical carcinogenesis 393
James E. Kalunig
9 genetic toxicology 445
R. Julian Preston and George R. Hoffmann
10 Developmental toxicology 481
John M. Rogers
UNIT IV TARGET ORGAN TOXICITY 525
11 toxic responses of the bloog 527
Jhon C. Bloom, Andrew E. Schade, and John T. Brandt
12 toxic responses of the immune system 559
Barbara L.F. Kaplan, Courtney E.W. SUlentic, Michael P. Holsapple, and Norbert E. Kaminski
13 toxic responses of the liver 639
Hratmut Jaeschke
14 toxic responses of the kidney 665
Rixk G. Schnellmann
15 toxic responses of the respiratory system 691
Gorge D. Leikauf
16 toxic responses of the nervous system 733
Virginia C. Moser, Michael Aschner, Rudy J. Richardson, and Martin A. Philbert
17 toxic responses of the ocular and visual system 767
Donald A. Fox and William K. Boyes
18 toxic responses of the heart and vascular system 799
Y. James Kang
19 toxic responses of the skin 839
Robert H. Rice and Theodora M. Mauro
20 toxic responses of the reproductive system 861
Paul M. D. Foster and L. Earl Gray Jr.
21 toxic responses of the endocrine system 907
Patricia B. Hoyer and Jodi A. Flaws
UNIT IV TOXIC AGENTS 931
22 toxic effetcs of pesticides 933
Lucio G. Costa
23 toxic effects of metals 981
Erik J. Tokar, WIndy A. Boyd, Jonathan H. Freedman, and Michael P. Waalkes
24 toxic effects of solvents and vapors 1031
James V. Bruckner, S. Satheesh Anand, and D. Alan Warren
25 toxic effects of radiation and radioactive materials 1113
David G. Hoel
26 toxic efects of plants and animals 1131
John B. Watkins, III
27 toxic effects of calories 1169
Martin J. Ronis, Kartik Shankar, and Thomas M. Badger
UNIT VI ENVIROMENTAL TOXICOLOGY 1187
28 nanotoxicology 1189
Gunter Oberdorster, Agnes B, Kane, Rebecca D. Klaper, and Robert H. Hurt
29 Air pollution 1231
Daniel L. Costa and Terry Gordon
UNIT VII APPLICATIONS OF TOXICOLOGY 1273
30 ecotoxicology 1275
Richard T. Di Giulio and Michael C. Newman
31 food toxicology 1305
Frank N. Kotsonis and George A. Burdock
32 analytical and forensic toxicology 1357
Bruce A. Goldberger and Diana G. Wilkins
33 clinical toxicology 1375
Louis R. Cantilena Jr.
34 Occupational toxicology 1391
Peter S. Thorne
35 regulatory toxicology 1413
Gary E. Marchant
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