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Introduction to The Pharmaceutical Sciences
CONTENTS
1 Introduction 1
PART I: DRUG CEHMISTRY 7
2 Drugs and their targetr 8
3 Ionization of drugs 26
4 Solubility and lipophilicity 42
PART II: DRUG DELIVERY 58
5 Transport across biological barriers 59
6 Drug absorption 89
7 Drug delivery systems 105
PART III: DRUG DISPOSITION 119
8 Drug diistribution 120
9 Drug excretion 138
10 Drug metabolism 155
11 Pharmacokinetic consepts 183
PART IV: DRUG ACTION 200
12 Ligands and receptors 201
13 Mechanisms of drug action 226
14 Dose-response relationships 246
PART V: DRUG THERAPY 262
15 Therapeutic variability 263
16 Drug interactions 278
17 Pharmacogenomics 294
PART VI: SPECIAL TOPICS 313
18 Biopharmaceutical drugs 314
19 Drug discovery and approval 340
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