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Clinical Pharmacokinetics and Pharmacodynamics: Concepts And Applications.

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CONTENTS

SECTION 1 BASIC CONSIDERATIONS
1 Therapeutic relevance 3
2 Fundamental concepts and terminology 17

SECTION II EXPOSURE AND RESPONSE AFTER A SINGLE DOSE
3 Kinetics following an intravenous bolus dose 49
4 Membranes and distribution 73
5 Elimination 111
6 Kinetics following an extravascular dose 159
7 Absorption 183
8 Response following a single dose 217

SECTION III THERAPEUTIC REGIMENS
9 Therapeutic window 245
10 Constant-rate input 259
11 Multiple-dose regiments 293

SECTION IV INDIVIDUALIZATION
12 Variability 333
13 Genetics 357
14 Age, weight, and gender 373
15 Disease 403
16 Nonlinearities 445
17 Drug interactions 483
18 initiating and managing therapy 527

SECTION V SUPPLEMENTAL TOPICS
19 Distribution kinetics 561
20 Metabolites and drug response 603
21 Protein drugs 633
22 Prediction and refinement of human kientics from in vitro, preclinical, and early clinical data 663

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Series Title

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Call Number

615.7-2 Row C

Publisher

Philadelphia : Wolters Kluwer Health., 2011

Collation

ed.4-cet.1. xxii, 839 hal. : ilus. ; 26 cm Index.

Language

Indonesia

ISBN/ISSN

978-0-7819-5009-7

Classification

615.7-2 Row C

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Edition

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