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Dermal Absorption Models in Toxicology and Pharmacology

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This book provide current approaches and technique by which dermal absorption may be quantitated utilizing end points relative to these two disciplines. There are number of different experimental methods and mathematical modeling approaches in use today. Most are rooted in disciplines outside toxicology, yet their methods are applied to dermal absorption. This book serves as a bridge between general considerations in risk assessment and systematic toxicology texts. The first four chapter introduce and overview both the structure and function of skin as well as the in vitro and in vivo experimental approaches available for assessing dermal absorption of drugs and chemicals. This is followed by mathematical or so-called in silico models to quantitating percutaneous absorption, including physiological-based pharmacokinetic modeling and quantitative structure-activity relationship methods. The next chapters deal with applications of these techniques to the risk assessment process. The remainder of the book discusses scenarios in which unique properties of the chemicals studied or the matrix in which they are exposed must be considered, including volatile compounds or dosing in soils. In many dermal absorption studies, unique properties of compounds or additives may alter a compound's absorption. These include vasoactive chemicals, the use of penetration enhancers, or exposure in complex chemical mixtures. The book wraps up with a comparative analysis of chemical permeability in human and animal skin. This book reviews basic principles, presents in-depth discussions of the most widely used technique, and offers select case studies of how these technique have been applied under different scenarios. It serves as a concise introduction and review of the application of dermal absorption to problems in toxicology and pharmacology for both researchers in this field and graduate courses overviewing this area.

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Detail Information

Series Title

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Call Number

616.5 Riv D

Publisher

New York : Taylor & Francis., 2006

Collation

Ed.1-Cet.1. 374 hal. Ilus. ; 24,5 cm Index. Hlm 36

Language

Indonesia

ISBN/ISSN

0-415-70036-1

Classification

616.5 Riv D

Content Type

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Media Type

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Carrier Type

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Edition

NULL

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