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Phytochemicals as Bioactive Agents
Epidemiological evidence has concictenly provided positive correlations between certain diets, specific foods, and disease expression. Diets rich in fruits, vegetables, and grains have been associated with disease prevention. During the assessment of the chemical components of these food groups, it became apparent that health benefits did not correlate solely with nutrient content. In fact, many phytochemicals were identified that displayed bioactivity in prevention of cancer, heart disease, and other disease. Further evaluation of the mechanism of action of these chemicals remains essential to our understanding of which chemicals are effective at low concentrations within the existing food supply. Stategies used to identify bioactive phytochemicals are presented by in chapter 1. Chapter 2qsar and molecular modeling of bioactive phyto-phenlolics. Chapter 3 chemoprevention by phytochemical modifiers of carcinogen metabolism. Chapter 4 clinical trial design for evaluating phytochemical bioactivity. Chapter 5 the use of fermentable fibers to manage the gastrointestinal ecosystem. Chapter 6 phytoantimicrobial (PAM) agnets as multifunctional food additives. Chapter 7 the protective effect of tea on cancer: human evidence. Chapter 8 effect of genistein o growth of human breast cancer cells in vitro and in vivo. Chapter 9 cancer prevention by carotenois and curcumin. Chapter 10 alfalfa saponins: chemistry and application. Chapter 11 saw palmetto: critical review, chemistry, and application. Chapter 12 effect of garlic on serum cholesterol levels. Chapter 13 bioactives in rice bran and rice bran oil. Chapter 14 designing functional foods to enhance health.
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