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Nutritional Status of Patient with Reccurent Aphthous Stomatitis: A Systematic Review of Observational Study

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Recurrent aphthous stomatitis (RAS) is an oral mucosal disease, one of the predisposing
factors for RAS is nutritional deficiency. Parameters of nutritional status included
anthropometry, dietary assessment, and serological examination. The nutritional status of
RAS sufferers has good macronutrients but low micronutrients. The purpose of this study was
to review the nutritional status of RAS patients worldwide and its relationship to the number
of ulcers, diameter, severity, and frequency of RAS recurrence. The Preferred Reporting
Items for Systematic Review and Meta-analysis (PRISMA) guidelines were used in
structuring this systematic review. The PICO (population, intervention, comparison,
outcome) and Risk of Bias Assessment tool for Non-randomized Studies (RoBANS) were used.
Of twelve research articles in this study, seven used the case-control method, four used a
cross-sectional study, and 1 article used a retrospective study. All studies used blood
samples, and 2 articles also used saliva samples. This study found vitamin D, B12, and E
deficiencies in RAS patients and no lack of folate, iron, zinc, and vitamins A and C. Vitamin
D deficiency has a significant relationship with increasing ulcers. The nutritional status of
patients with RAS showed a micronutrient deficiency and its relationship with increasing
ulcers.
Keywords: Hematinic deficiency, Micronutrient, Recurrent aphthous stomatitis, Vitamin.

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Series Title

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Call Number

616.31 Qis N

Publisher

FKG UNPAD JATINANGOR : FKG Unpad., 2022

Collation

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Language

English

ISBN/ISSN

160110180084

Classification

616.31

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Edition

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Subject(s)

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