Manuscript

The Potential Of Hyperbaric Oxygen Therapy In Enhancing Vegf : A Scoping Review (Overview On Angiogenesis Of Regenerative Endodontic Treatment)

---

Introduction: Hyperbaric oxygen therapy (HBOT) is known to have an
effect in stimulating angiogenesis. Angiogenesis in regenerative endodontics is
needed to improve blood supply, carry oxygen, nutrients, and stem cells which are
useful for regenerating the pulp. Regenerative endodontics in mature permanent
teeth has not been widely reported in studies because of the possible limitations in
producing apical bleeding that capable to improve angiogenesis. This study aims
to determine the effect of HBOT on angiogenesis by observing VEGF which is one
of the most important proangiogenic growth factors. Methods: This study used a
scoping review method with PRISMA-ScR analysis. Search for articles through
PubMed, Cochrane Library, ScienceDirect, and Google Scholar with inclusion
criterias are effects of hyperbaric oxygen therapy on angiogenesis, effects of
hyperoxia on angiogenesis, VEGF expression on hyperoxia, effects hyperbaric
oxygen therapy on VEGF expression, in Indonesian or English, and publication
year limit from 2006 to 2021 and exclusion criterias are articles without full text
and VEGF expression in normoxic and normobaric conditions. Results: Six articles
reported there are significant increase of VEGF in HBOT group, one article
reported an increase of VEGF but not significant, and one article reported no
increase of VEGF in HBOT group. Conclusion: HBOT increases angiogenesis
which is indicated by an increase of VEGF level. The analysis of articles show that
angiogenesis at the molecular level of several tissues involves the same growth
factor thus proving that HBOT also has a potential to increase angiogenesis that
needed for regenerate the pulp in endodontic regenerative treatment.
Keywords: Angiogenesis, Hyperbaric Oxygen Therapy (HBOT), pulp
regeneration, regenerative endodontic, Vascular endothelial growth factor
(VEGF).

---

Availability @Fakultas Kedokteran Gigi

No copy data

Detail Information

Series Title

-

Call Number

611 Wib T

Publisher

FKG UNPAD JATINANGOR : FKG Unpad., 2021

Collation

-

Language

Indonesia

ISBN/ISSN

160110170081

Classification

611

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

-

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment