Perbandingan Pemberian Metoprolol Tartrat dengan Lidokain secara Intravena terhadap Perubahan Tekanan Darah dan Laju Nadi Akibat Tindakan Laringoskopi dan Intubasi

Main Authors: Koswara, Yovita, Pradian, Erwin, Redjeki, Ike Sri
Format: Article info application/pdf eJournal
Language: eng
Published: Faculty of Medicine, Universitas Padjadjaran , 2014
Online Access: http://journal.fk.unpad.ac.id/index.php/jap/article/view/309
http://journal.fk.unpad.ac.id/index.php/jap/article/view/309/pdf_26
ctrlnum article-309
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="en-US">Perbandingan Pemberian Metoprolol Tartrat dengan Lidokain secara Intravena terhadap Perubahan Tekanan Darah dan Laju Nadi Akibat Tindakan Laringoskopi dan Intubasi</title><creator>Koswara, Yovita</creator><creator>Pradian, Erwin</creator><creator>Redjeki, Ike Sri</creator><subject lang="en-US"/><subject lang="en-US"/><description lang="en-US">Tindakan laringoskopi dan intubasi endotrakeal dapat menyebabkan tekanan darah dan laju nadi naik secara mendadak akibat rangsangan terhadap sistem simpatis. Tujuan penelitian ini untuk mengetahui pengaruh pemberian metoprolol 5 mg intravena dibandingkan dengan lidokain 1,5 mg/kgBB untuk mengurangi lonjakan hemodinamik akibat laringoskopi intubasi. Penelitian ini dilakukan secara uji klinis acak terkontrol buta ganda terhadap 40 pasien dengan status fisik American Society of Anesthesiologist (ASA) I&#x2212;II yang menjalani operasi dengan teknik anestesi umum di Rumah Sakit Dr. Hasan Sadikin Bandung dari bulan Juli&#x2212;Agustus 2013. Subjek dibagi menjadi 2 kelompok, yaitu kelompok yang diberikan metoprolol 5 mg intravena atau lidokain 1,5 mg/kgBB 3 menit sebelum tindakan laringoskopi dan intubasi. Data penelitian dianalisis dengan uji-t, dengan nilai p&lt;0,05 dianggap bermakna. Analisis statistik menunjukkan bahwa pada 2 menit dan 3 menit setelah intubasi antara kedua kelompok didapatkan perbedaan bermakna pada seluruh&#xA0; parameter hemodinamik dengan nilai&#xA0; p&lt;0,05. Simpulan dari penelitian ini adalah metoprolol 5 mg secara intravena memberikan hasil lebih baik dibandingkan dengan lidokain 1,5 mg/kgBB dalam hal mengurangi lonjakan hemodinamik akibat tindakan laringoskopi intubasi.Kata kunci: Intubasi, laringoskopi, lidokain, metoprololComparison of Intravenous Metoprolol Tartrate and Lidocaine on Changes of Blood Pressure and Heart Rate During Laryngoscopy and IntubationLaryngoscopy and endotracheal intubation associated with a sudden rise in blood pressure and pulse rate due to stimulation of sympathetic activity. The aim of this study was to compare effectiveness of metoprolol 5 mg intavenously and lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and intubation. This was an experimental randomized double blind controlled trial study was conducted in 40 patients with American Society of Anesthesiologist (ASA) physical status I or II who will have surgery with general anesthesia techniques in Hasan Sadikin Hospital Bandung from July&#x2212;August 2013. Subjects were divided into two groups wich received metoprolol 5 mg intravenously or lidocaine 1.5 mg/kgBW 3 minutes before laryngoscopy and intubation. All data were analysed using t-test, with&#xA0; p value &lt; 0.05 considered significant. Statistical analysis showed that on second and third minutes after intubation and laryngoscopy showed a significant differences on hemodynamic parameter between two groups with&#xA0; p value &lt;0.05. The conclusions of this study are intravenous 5 mg of metoprolol found to be better than lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and&#xA0; intubation.Key words: Intubation, laryngoscopy, lidocaine, metoprolol&#xA0;DOI: 10.15851/jap.v2n2.309</description><publisher lang="en-US">Faculty of Medicine, Universitas Padjadjaran</publisher><contributor lang="en-US"/><date>2014-08-21</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Other:</type><type>Other:</type><type>File:application/pdf</type><identifier>http://journal.fk.unpad.ac.id/index.php/jap/article/view/309</identifier><source lang="en-US">Jurnal Anestesi Perioperatif; Vol 2, No 2 (2014); 153-161</source><source lang="id-ID">Jurnal Anestesi Perioperatif; Vol 2, No 2 (2014); 153-161</source><source>2337-7909</source><language>eng</language><relation>http://journal.fk.unpad.ac.id/index.php/jap/article/view/309/pdf_26</relation><recordID>article-309</recordID></dc>
language eng
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author Koswara, Yovita
Pradian, Erwin
Redjeki, Ike Sri
title Perbandingan Pemberian Metoprolol Tartrat dengan Lidokain secara Intravena terhadap Perubahan Tekanan Darah dan Laju Nadi Akibat Tindakan Laringoskopi dan Intubasi
publisher Faculty of Medicine, Universitas Padjadjaran
publishDate 2014
url http://journal.fk.unpad.ac.id/index.php/jap/article/view/309
http://journal.fk.unpad.ac.id/index.php/jap/article/view/309/pdf_26
contents Tindakan laringoskopi dan intubasi endotrakeal dapat menyebabkan tekanan darah dan laju nadi naik secara mendadak akibat rangsangan terhadap sistem simpatis. Tujuan penelitian ini untuk mengetahui pengaruh pemberian metoprolol 5 mg intravena dibandingkan dengan lidokain 1,5 mg/kgBB untuk mengurangi lonjakan hemodinamik akibat laringoskopi intubasi. Penelitian ini dilakukan secara uji klinis acak terkontrol buta ganda terhadap 40 pasien dengan status fisik American Society of Anesthesiologist (ASA) I−II yang menjalani operasi dengan teknik anestesi umum di Rumah Sakit Dr. Hasan Sadikin Bandung dari bulan Juli−Agustus 2013. Subjek dibagi menjadi 2 kelompok, yaitu kelompok yang diberikan metoprolol 5 mg intravena atau lidokain 1,5 mg/kgBB 3 menit sebelum tindakan laringoskopi dan intubasi. Data penelitian dianalisis dengan uji-t, dengan nilai p<0,05 dianggap bermakna. Analisis statistik menunjukkan bahwa pada 2 menit dan 3 menit setelah intubasi antara kedua kelompok didapatkan perbedaan bermakna pada seluruh parameter hemodinamik dengan nilai p<0,05. Simpulan dari penelitian ini adalah metoprolol 5 mg secara intravena memberikan hasil lebih baik dibandingkan dengan lidokain 1,5 mg/kgBB dalam hal mengurangi lonjakan hemodinamik akibat tindakan laringoskopi intubasi.Kata kunci: Intubasi, laringoskopi, lidokain, metoprololComparison of Intravenous Metoprolol Tartrate and Lidocaine on Changes of Blood Pressure and Heart Rate During Laryngoscopy and IntubationLaryngoscopy and endotracheal intubation associated with a sudden rise in blood pressure and pulse rate due to stimulation of sympathetic activity. The aim of this study was to compare effectiveness of metoprolol 5 mg intavenously and lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and intubation. This was an experimental randomized double blind controlled trial study was conducted in 40 patients with American Society of Anesthesiologist (ASA) physical status I or II who will have surgery with general anesthesia techniques in Hasan Sadikin Hospital Bandung from July−August 2013. Subjects were divided into two groups wich received metoprolol 5 mg intravenously or lidocaine 1.5 mg/kgBW 3 minutes before laryngoscopy and intubation. All data were analysed using t-test, with p value < 0.05 considered significant. Statistical analysis showed that on second and third minutes after intubation and laryngoscopy showed a significant differences on hemodynamic parameter between two groups with p value <0.05. The conclusions of this study are intravenous 5 mg of metoprolol found to be better than lidocaine 1.5 mg/kgBW to attenuate hemodynamic response evoked by laryngoscopy and intubation.Key words: Intubation, laryngoscopy, lidocaine, metoprolol DOI: 10.15851/jap.v2n2.309
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