Senyawa Damara-20,24-dien-3-on yang beraktivitas Sitotoksis terhadap Sel Mcf-7 dari Kulit Batang Chisocheton Marcrophyllus (Meliaceae)

Main Authors: Nurlelasari, Nurlelasari, Ferdiana, Nurabi, Mauluddin, Subekti, Harneti, Desi, Moektiwardoyo, Moelyono, Abdullah, Rizky, Supratman, Unang, Awang, Khalijah
Format: Article info application/pdf Journal
Language: ind
Published: Universitas Padjadjaran , 2015
Online Access: http://jurnal.unpad.ac.id/ijas/article/view/15062
http://jurnal.unpad.ac.id/ijas/article/view/15062/7139
ctrlnum article-15062
fullrecord <?xml version="1.0"?> <dc schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"><title lang="id-ID">Senyawa Damara-20,24-dien-3-on yang beraktivitas Sitotoksis terhadap Sel Mcf-7 dari Kulit Batang Chisocheton Marcrophyllus (Meliaceae)</title><creator>Nurlelasari, Nurlelasari</creator><creator>Ferdiana, Nurabi</creator><creator>Mauluddin, Subekti</creator><creator>Harneti, Desi</creator><creator>Moektiwardoyo, Moelyono</creator><creator>Abdullah, Rizky</creator><creator>Supratman, Unang</creator><creator>Awang, Khalijah</creator><description lang="id-ID">AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus,&#xA0; MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus,&#xA0; Meliaceae</description><publisher lang="id-ID">Universitas Padjadjaran</publisher><contributor lang="id-ID"/><date>2015-12-31</date><type>Journal:Article</type><type>Other:info:eu-repo/semantics/publishedVersion</type><type>Journal:Article</type><type>File:application/pdf</type><identifier>http://jurnal.unpad.ac.id/ijas/article/view/15062</identifier><source lang="id-ID">Indonesian Journal of Applied Sciences; Vol 5, No 3 (2015)</source><source lang="en-US">Indonesian Journal of Applied Sciences; Vol 5, No 3 (2015)</source><source>2581-1991</source><source>2089-9203</source><language>ind</language><relation>http://jurnal.unpad.ac.id/ijas/article/view/15062/7139</relation><rights lang="id-ID">Copyright (c) 2017 Indonesian Journal of Applied Sciences</rights><recordID>article-15062</recordID></dc>
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author Nurlelasari, Nurlelasari
Ferdiana, Nurabi
Mauluddin, Subekti
Harneti, Desi
Moektiwardoyo, Moelyono
Abdullah, Rizky
Supratman, Unang
Awang, Khalijah
title Senyawa Damara-20,24-dien-3-on yang beraktivitas Sitotoksis terhadap Sel Mcf-7 dari Kulit Batang Chisocheton Marcrophyllus (Meliaceae)
publisher Universitas Padjadjaran
publishDate 2015
url http://jurnal.unpad.ac.id/ijas/article/view/15062
http://jurnal.unpad.ac.id/ijas/article/view/15062/7139
contents AbstrakSenyawa triterpenoid damaran, damara-20,24-dien-3-on telah diisolasi dari kulit batang Chisocheton Marcrophyllus (Meliaceae). Struktur kimia kedua senyawa tersebut telah ditetapkan berdasarkan data spektroskopi dan perbandingan data spektra yang diperoleh dari literatur. Senyawa damara-20,24-dien-3-on menunjukkan aktivitas sitotoksik terhadap sel kanker payudara manusia MCF-7 dengan nilai IC50 28 mM.Kata Kunci : aktivitas sitotoksik, sel MCF-7, triterpenoid damaran, Chisocheton Marcrophyllus, MeliaceaeAbstractDammarane triterpenoid, damara-20,24-dien-3-on has been isolated from the bark of Chisocheton Marcrophyllus (Meliaceae). Chemical Structure of compound was dtermined on the basic of spektroscopic data and comparison with those spectra data previously reported. Compound damara-20,24-dien-3-on exhibited cytotoxic activity againts MCF-7 human breast cancer cell lines with IC50 value 28 mM respectively.Kata Kunci : cytotoxic activity, MCF-7 cell, dammarane triterpenoid, Chisocheton Marcrophyllus, Meliaceae
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